- the generic street name (and often the official name) of the primary retail street of a village, town, or small city in the United States, Canada, Ireland, some parts of Scotland and also in some countries in central Europe.
- (idiomatic, North America) the interests of everyday working-class people and small business owners.
- "...Wall Street has surged back to pre-crisis levels of compensation evan as Main Street continues to struggle." - Chrystia Freeland
generic name of a primary street