thiopyridone

English edit

thiopyridone (countable and uncountable, plural thiopyridones)

(organic chemistry) A derivative of a pyridone in which the carbonyl oxygen atom is substituted by one of sulfur
- 2015 September 26, “C-STrap Sample Preparation Method— In-Situ Cysteinyl Peptide Capture for Bottom-Up Proteomics Analysis in the STrap Format”, in PLOS ONE‎^[1], →DOI:
  Thiopropyl Sepharose™ 6B (GE Healthcare) has been used widely over several decades to reversibly bind biological molecules containing the sulfhydryl groups—the 2-thiopyridyl disulphide group of the sepharose matrix reacts with a molecule containing a free thiol to form a mixed disulfide; during the reaction thiopyridone is formed while the bound target molecule is released by addition of a reducing agent.