Fans of the show were closely watching for plot developments on the Cophine front because Delphine had been presumed to be dead after last season's finale, which ended on a cliffhanger that saw Delphine being shot.
2016, Bethany A. Scettrini, "Fan Responses to Orphan Black and The 100 via Blogs, Fan Fiction, and Ship Wars", thesis submitted to Baylor University, page 50:
For instance, my OTP is Cophine—Cosima and Delphine from Orphan Black. This means my fannish identity and online fandom involves reading Cophine-centric fanfiction, watching or making Cophine fanvids, creating angsty or hopeful playlists on 8tracks, buying t-shirts and tote bags on Redbubble, liveblogging new episodes, forming group chats to discuss the show, and, as an academic fan, I even write research papers about Orphan Black and Cophine.
Kennedy, who previously penned the Orphan Black: Deviations comic, told IGN the comic will also see the old sestras and “Cophine” drawn into “an international mystery.”