Perhaps related to bubo and/or carbuncle.
bubukle (plural bubukles)
- (obsolete, nonce word) A red pimple.
- William Shakespeare, Henry V
- His face is all bubukles, and whelks, and knobs, and flames o' fire; and his lips blows at his nose, and it is like a coal of fire, sometimes plue and sometimes red; but his nose is executed, and his fire's out.