oncometabolite
English
editEtymology
editFrom onco- + metabolite.
Noun
editoncometabolite (plural oncometabolites)
- (biochemistry, pathology) Any metabolite that is associated with a cancer
- 2015 July 11, “Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes”, in PLOS ONE[1], :
- Due to this pleiotropic function for dysregulating biological events, 2-HG is regarded as an oncometabolite that exerts tumor-inducing actions, and searches for IDH gene mutations have been performed in various types of malignancies [1 ,2 ].