SPE (plural SPEs)
- (chemistry) Initialism of solid-phase extraction.
- Initialism of sales process engineering.
- Initialism of seriously painful experience.
- (space science) Initialism of solar particle event.
- Society of Petroleum Engineers
- (linguistics) The Sound Pattern of English
- EPS, EPs, ESP, Eps, PES, PEs, PSE, SEP, Sep, Sep., eps, esp, esp., pes, sep