screwup (plural screwups)
- (colloquial) A substantial mistake, usually causing problems for more people than just the person or group who made it.
1977, John Osborne, White House watch: the Ford years, page 147:
- The Ford administration emerged in better shape than it deserved from the fantastic screw-up that preceded the release of the Rockefeller...
- (colloquial) A person who often makes substantial mistakes.