- The state of being transgender. (See usage notes)
- (offensive) A purported ideology behind transgender identities, trans activism and trans rights movements. (Compare homosexual agenda.)
- The term is common in science and social science literature, but is little used by the trans community; GLAAD says the term is primarily used by anti-transgender activists, and recommends synonyms like "being transgender". Julia Serano agrees that it has been appropriated by transphobic authors in recent years and used as though it referred to an ideology rather than a state of being; she does not consider it offensive per se but notes that it has started to be objected to.
- Oxford Dictionaries,