hydroxyphosphate (plural hydroxyphosphates)
- (inorganic chemistry) Any of three anions formed by replacing one, two or three oxygen atoms of a phosphate ion by a hydroxyl group; any salt containing such an anion
- 2015 September 7, Orestis A Panagiotou et al., “Effect of bivalent human papillomavirus vaccination on pregnancy outcomes: long term observational follow-up in the Costa Rica HPV Vaccine Trial”, in BMJ : British Medical Journal, volume 351, DOI:10.1136/bmj.h4358:
- Two pooled analyses by the vaccine manufacturer did not find a difference in miscarriage risk for pregnancies conceived in a risk window of −30 to 45 days from bivalent HPV vaccination. 26 27 Similarly, a lack of association was observed in placebo controlled trials evaluating the efficacy and safety of the bivalent HPV vaccine. 28 29 Nevertheless, a subgroup analysis in black women in the Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I/II trials showed an increased risk of miscarriage compared with unvaccinated pregnancies for the quadrivalent HPV vaccine that has a different adjuvant (amorphous aluminum hydroxyphosphate sulfate). 30 However, no results were reported for restricting the endpoint by different periods of gestation as in our study, which did not confirm the overall increased miscarriage risk in FUTURE I/II using longer follow-up and a larger number of pregnancies.