- (medicine, pathology) Abnormal softening of organs or tissues of the human body. [from 19th c.]
- 1860, Rudolf Ludwig Karl Virchow, Cellular Pathology as Based Upon Physiological and Pathological Histology, page 318:
- As soon, namely, as a process of this sort sets in in a compound organ, as for example, a muscle, a palpable myo-malacia is certainly produced when all the muscular elements at a given point are at once affected; but it happens far more frequently that, in the course of a muscle, only a comparatively small number of primitive fasciculi are affected, whilst the others remain almost intact.
- (medicine, obsolete) An abnormal craving for certain types of food. [from 17th c.]
softening of organs or tissue