metyrapone

English

Chemical structure of metyrapone

Etymology

From meth- +‎ (dip)yr(idyl) +‎ -a- +‎ (pro)p(an)one.

Pronunciation

• (Received Pronunciation) IPA^(key): /mɪˈtɪ.ɹə.pəʊn/, /mɪˈtʌɪ.ɹə.pəʊn/
• (General American) IPA^(key): /məˈtɪɹ.əˌpoʊn/

Noun

metyrapone (uncountable)

1. (pharmacology) A compound that inhibits the enzyme 17β-hydroxylase and prevents synthesis of glucocorticoids and mineralocorticoids by the adrenal gland, used chiefly for assessment of feedback control of the hypothalamic–pituitary axis in adrenal disease, and sometimes in the treatment of Cushing's syndrome and resistant edema; 2-methyl-1,2-di-3-pyridyl-1-propanone, C₅H₄N·CO·C(CH₃)₂·C₅H₄N.

References

• “metyrapone”, in Lexico, Dictionary.com; Oxford University Press, 2019–2022.
• “metyrapone”, in Merriam-Webster Online Dictionary, Springfield, Mass.: Merriam-Webster, 1996–present.